The association of C789A polymorphism in the dopamine beta-hydroxylase gene (DBH) and aggressive behaviour in dogs

The genetic basis of aggressive behaviour has been examined extensively, including analysis genes encoding neurotransmitters, signalling molecules and regulatory enzymes, as well their synthesis degradation. Dopamine beta-hydroxylase, an enzyme catalysing the conversion dopamine into norepinephrine in synaptic endings, significantly affects modulation emotional states behaviour. aim this study was to determine association C789A polymorphism canine beta-hydroxylase gene ( DBH ) dogs. A total 110 dogs different breeds were analysed. All animals classified according individual behavioural characteristics, defined by a veterinary interview observation. Polymorphism analysed using ACRS-PCR (amplification created restriction site-polymerase chain reaction) method. Significant differences genotypes allele frequency between non-aggressive observed (χ 2 = 16,232, P 0.0003). In dogs, CC genotype (0.788) C (0.815) most frequent while frequencies lower (0.361 0.404, respectively). obtained results indicate that is promising candidate for study.